Renal Considerations in the Heat Stress Recommendations (Aim2)

Indiana University

Status

Completed

Conditions

Hot Weather; Adverse Effect

Dehydration

Hyperthermia

Kidney Injury

Kidney Dysfunction

Treatments

Procedure: No fluid replacement

Procedure: Fluid replacement

Study type

Interventional

Funder types

Other

Identifiers

NCT05458843

15402

Details and patient eligibility

About

An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is largely unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration that elicit oxidative stress and inflammation in the renal tubules. The purpose of this study is to determine whether hydration status modifies the development of renal oxidative stress and inflammation.

Enrollment

18 patients

Sex

All

Ages

18 to 44 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Men and women
18-44 y old
Body mass index ≤35.0 kg/m2
Self-reported to be healthy

Exclusion criteria

Not within defined age range
Estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2
Body mass index >35.0 kg/m2
Current or history of any renal disease, heart disease, stroke, immune or autoimmune disease, and/or gastrointestinal disease/surgery
Hypertension during screening (systolic blood pressure >139 or diastolic blood pressure >89)
Using medications that blunt the physiological response to exercise (e.g., beta blockers)
Prescription medication with a known side effect of impaired temperature regulation or fluid balance (e.g., diuretics)
Positive pregnancy test at any time during the study or breast feeding
Current tobacco or electronic cigarette use or consistent use within the last 2 years
Answered "Yes" to any question on Page 1 of the PAR-Q+.