Renal Denervation in Patients After Acute Coronary Syndrome (ACSRD)

Meshalkin Research Institute of Pathology of Circulation

Status and phase: Unknown; Phase 2

Conditions: Acute Coronary Syndrome; Arterial Hypertension

Treatments: Drug: Lisinopril; Procedure: Renal denervation; Drug: Metoprolol

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT01901549

AMIRD

Details and patient eligibility

About

This study is aimed to evaluate the effect of renal denervation to decreasing blood pressure and left ventricle remodeling progression in patients after acute coronary syndrome.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute Q negative myocardium infarction (during first 14 days)
• non stable angina
• significant stenosis
• BP > 140/90 torr. during more than 1 year

Exclusion criteria

• absence of arterial hypertension
• Thrombolysis during previous 24 hours
• indications for CABG

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

PCI+Renal denervation

Active Comparator group

Treatment:

Drug: Metoprolol

Procedure: Renal denervation

Drug: Lisinopril

PCI alone

Active Comparator group

Treatment:

Drug: Metoprolol

Drug: Lisinopril