Renal Nerve Denervation(RDN) and Renal Function

Zhengrong Huang

Status: Enrolling

Conditions: Effects of RDN on Renal Function

Study type: Observational

Funder types: Other

Identifiers

NCT05612906

2022-Renal nerve denervation

Details and patient eligibility

About

Current studies have found the efficacy of RDN in the treatment of hypertension, however, the safety of RDN in renal function is still lacking. Therefore, the investigators are aimed to study the effect of RDN on renal function.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1.18<age≤75 years; 2.clinic blood pressure ≥ 140/90 mmHg or 24-hour ambulatory blood pressure monitoring average blood pressure ≥ 135/85 mmHg after taking 3 or more antihypertensive drugs for more than 4 weeks; 3.essential hypertension, renal parenchymal hypertension, or hypertension patients who are willing to receive RDN ; 4.who signed informed consent and were approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University.

Exclusion criteria

• pregnant women or lactating patients;

  • identified secondary hypertension or Pseudo hypertension;

    • whose renal arteries were unsuitable for ablation

      • obvious bleeding tendency and blood system diseases;

        • malignant tumors or end-stage diseases; ⑥Severe peripheral vascular disease, abdominal aortic aneurysm; ⑦A history of the acute coronary syndrome within two weeks; ⑧acute or severe systemic infection; ⑨drug or alcohol dependence or refusal to sign informed consent.