Renal Perfusion and the Development of AKI Following Traumatic Injury (PERTAKI)

King's College Hospital NHS Trust

Status

Enrolling

Conditions

AKI (Acute Kidney Injury) Due to Trauma

AKI - Acute Kidney Injury

Traumatic Haemorrhagic Shock

Treatments

Device: Urinary oxygen tension.

Device: Sublingual incident dark field videomicroscopy

Device: Ultrasound (including contrast enhanced ultrasound)

Study type

Observational

Funder types

Other

Identifiers

NCT06917053

334289

Details and patient eligibility

About

Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age > 18 years
Within 24 hours of ICU admission following traumatic injury
Received any blood products during initial resuscitation
Lactate > 2 mmol/l at any stage prior to study enrolment

Exclusion criteria

Known intolerance to Sonovue or any other ultrasound contrast agent
Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative
Known CKD 4 or end stage renal failure
Pregnancy