Renal Protocol Protection in CKD Patients

Seoul National University

Status: Active, not recruiting

Conditions: CKD; HCC

Treatments: Other: Standard dose CT contrast media; Other: low dose CT contrast media

Study type: Interventional

Funder types: Other

Identifiers

NCT04024514

SNUH-2019-0343

Details and patient eligibility

About

This study aims to investigate whether acceptable image quality is achievable using low contrast media dose and low keV imaging in chronic kidney disease.

Enrollment: 52 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• High risk group for developing HCC
• Scheduled contrast-enhanced CT for HCC diagnosis or surveillance
• chronic kidney disease (Estimated GFR < 60mL/min/1.73m2)

Exclusion criteria

• not a high risk group for developing HCC
• congestive hepatopathy
• on dialysis
• no venous access on forearm
• anticipated beam hardening artifact due to prosthesis
• relative/absolute contra-indication of contrast-enhanced CT except CKD (Estimated GFR < 60mL/min/1.73m2)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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52 participants in 2 patient groups

Low dose

Experimental group

Description:

Low CT contrast media dose

Treatment:

Other: low dose CT contrast media

Standard dose

Active Comparator group

Description:

Standard CT contrast media dose

Treatment:

Other: Standard dose CT contrast media