Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal

University of Turin

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Device: RRT plus ECCO2R

Study type: Interventional

Funder types: Other

Identifiers

NCT02595619

CE 0068144

Details and patient eligibility

About

This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows reduction of tidal volume and plateau pressure. Systemic Inflammatory Response and Safety Variables will also be analysed.

Enrollment: 14 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with acute kidney injury (AKI) requiring renal-replacement therapy and mechanical ventilation of duration ≥ 48 hours

Exclusion criteria

• little chance of survival at 24 h (according to clinical judgment), pregnancy, mechanical ventilation with expected duration lower than 48h, age under 18 and over 90

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

RRT plus ECCO2R

Experimental group

Treatment:

Device: RRT plus ECCO2R