Renal Resistive Index as a Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in Sepsis

Tanta University

Status: Enrolling

Conditions: Renal Resistive Index; Acute Kidney Injury; Sepsis

Treatments: Diagnostic Test: Renal resistive index

Study type: Observational

Funder types: Other

Identifiers

NCT06009445

36264MS189/5/23

Details and patient eligibility

About

We aim from this study to investigate the role of renal resistance index (RRI) in evaluation of Acute kidney injury development and fluid administration in sepsis patients considering the change in RRI values over 7 days from admission as a predictor of AKI development

Full description

Acute kidney injury (AKI) is one of the most common problems in critically ill patients in the clinic. AKI can be caused by various factors, such as hypovolemia, shock, major surgery, trauma, and heart failure, of which sepsis is the most common

Enrollment: 45 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 21 years
• meet Sepsis 3 criteria (potential source of infection , host response and organ dysfunction) but not in septic shock.

Exclusion criteria

• patients during pregnancy.
• patients with hepatorenal syndrome.
• Poor abdominal echogenicity eg.(morbid obesity ,increase intra abdominal pressure )
• Severe acute or chronic renal insufficiency .
• Dialysis dependency.
• Renal transplantation.
• Known renal artery stenosis.
• Mono-kidney, kidney tumor, anatomic kidney abnormalities.

Trial design

45 participants in 2 patient groups

AKI group

Description:

Acute kidney injury (AKI) was defined according to the Kidney Disease Improving Global Outcome (KDIGO) classification using both creatinine and urine output criteria. The KDIGO guidelines define AKI as follows: * Increase in serum creatinine by ≥0.3 mg/dL (≥26.5 micromol/L) within 48 hours, or * Increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior seven days, or * Urine volume \<0.5 mL/kg/hour for six hours

Treatment:

Diagnostic Test: Renal resistive index

Non AKI group

Description:

Patients who will no develop Acute kidney injury (AKI).

Treatment:

Diagnostic Test: Renal resistive index