Renal Resistive Index as an Indicator of Lupus Nephritis Severity and Systemic Lupus Activity

Kasr El Aini Hospital

Status: Completed

Conditions: Lupus Glomerulonephritis; Systemic Lupus Erthematosus; Lupus Flare

Treatments: Diagnostic Test: colour doppler of the renal artery and measurement of resistive index

Study type: Interventional

Funder types: Other

Identifiers

NCT06757725

MS-632-2022 (Other Identifier)

Details and patient eligibility

About

The study explores the role of the colour Doppler scanning of the renal arteries and its relation to the degree of disease affection in lupus nephritis

Full description

we have recruited patients into 3 groups The first group is patients with lupus nephritis The second groups is patients with systemic lupus erythromatosus without nephritis The third groups is normal healthy controls we explored the association of colour Doppler and the renal resistive index with the degree of the renal affection in lupus nephritis

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1. Systemic lupus erythematosus. 2. Lupus nephritis. 3. Adults >18 years old.

Exclusion criteria

• 1. End Stage Renal Disease. 2. Diabetes Mellitus. 3. Heart failure. 4. Hepatic diseases. 5. Obstructive nephropathy. 6. Renal artery stenosis or occlusion.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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75 participants in 3 patient groups

Patients with lupus nephritis

Active Comparator group

Description:

Theses are 25 patients diagnosed with lupus nephritis

Treatment:

Diagnostic Test: colour doppler of the renal artery and measurement of resistive index

Lupus without nephritis

Active Comparator group

Description:

Theses are 25 patients diagnosed with lupus without evidence of nephritis

Treatment:

Diagnostic Test: colour doppler of the renal artery and measurement of resistive index

Healthy control

No Intervention group

Description:

Patients who are healthy volunteers with no evidence of nephritis or systemic lupus