Renal Response to Lower Body Negative Pressure in Pre-hypertensive States

PD Dr. Grégoire Wuerzner

Status and phase: Completed; Phase 4

Conditions: Hypertension; Resistant Hypertension; Obesity; White Coat Hypertension

Treatments: Drug: Candesartan cilexetil; Other: Lower body negative pressure (LBNP)

Study type: Interventional

Funder types: Other

Identifiers

NCT01734096

PZ00P3_121655

Details and patient eligibility

About

The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to orthostatic stress.

Enrollment: 78 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI > 30 Kg/m2 (obesity group)
• office BP >140/90 and daytime ambulatory blood pressure <135/85 (white coat hypertension group) _daytime abpm >135/85 mm Hg or nighttime abpm 120/70

Exclusion criteria

• History of allergic reaction
• Diabetes type 1 or type 2
• History of renal artery stenosis
• Acute illness

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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78 participants in 4 patient groups

control group

Active Comparator group

Description:

healthy volunteer

Treatment:

Other: Lower body negative pressure (LBNP)

Drug: Candesartan cilexetil

obesity group

Active Comparator group

Description:

Patients with BMI \>30 Kg/m2

Treatment:

Other: Lower body negative pressure (LBNP)

Drug: Candesartan cilexetil

white coat hypertension group

Active Comparator group

Description:

Patients with office blood pressure \>140/90 mmHg and ambulatory daytime blood pressure \<135/85 mmHg

Treatment:

Other: Lower body negative pressure (LBNP)

Drug: Candesartan cilexetil

Resistant hypertension

Active Comparator group

Description:

Patients with ambulatory blood pressure \> 135/85 mm Hg (day) or \>120/70 mm Hg (night) with 3 antihypertensive drugs with direct observance of drug taking.

Treatment:

Other: Lower body negative pressure (LBNP)