REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)

University Hospital of Bordeaux

Status: Completed

Conditions: Cardiac Surgery; Cardiopulmonary Bypass; Renal Transplant Recipient

Treatments: Other: standard of care

Study type: Observational

Funder types: Other

Identifiers

NCT04979754

SAR Sud study one

Details and patient eligibility

About

In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.

Full description

Post-operative mortality after cardiac surgery is increased in renal transplant recipients, compared with general population of cardiac surgery, or with kidney transplant recipients not undergoing cardiac surgery. If the survival of this specific population is now well studied, the long-term renal outcome is much less studied. Previous studies show a trend for increased risk of allograft dysfunction and need for permanent dialysis. This study proposes to compare long term renal outcome between renal transplant recipients and non-renal transplant recipients.

Enrollment: 93 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for Renal Transplant Recipients group:

• Previous renal transplantation
• Who underwent cardiac surgery with CPB

Inclusion Criteria for Non Renal Transplant Récipients group:

• No previous renal transplantation
• Who underwent cardiac surgery with CPB
• Apparied with Renal Transplant récipients with the 5 following criteria : age, sex, previous diagnosis of diabete, type of cardiac surgery (isolated coronary artery bypass graft, valvular surgery, aorta surgery, combined surgery), best glomerular filtration rate with CKD-EPI formula at +/- 15 ml/min, in the 3 pre-operative months

Exclusion Criteria:

• Patients requiring mechanical circulatory support (Extracorporeal Membrane Oxygenation)
• Pre-operative permanent dialysis
• Aorta dissection extended to renal arteries
• Non-elective surgery for infective endocarditis
• Previous hepatic, pancreatic or cardiac transplantation
• Death in the 30 first days after cardiac surgery
• Patient not meeting the inclusion criteria

Trial design

93 participants in 2 patient groups

RENAL TRANSPLANT RECIPIENTS

Description:

All patients with previous renal transplantation undergoing cardiac surgery with cardiopulmonary bypass

Treatment:

Other: standard of care

NON RENAL TRANSPLANT RECIPIENTS

Description:

All patients without previous renal transplantation undergoing cardiac surgery with cardiopulmonary bypass

Treatment:

Other: standard of care