Renoprotective Effect of Nisoldipine and Lisinopril in Type 1 Diabetic Nephropathy

Steno Diabetes Centers

Status and phase: Completed; Phase 4

Conditions: Diabetic Nephropathy

Treatments: Drug: lisinopril; Drug: nisoldipine

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00311870

KA 92126

Details and patient eligibility

About

The aim of the study was to compare the renoprotective effect of a long acting calcium antagonist (nisoldipine) with an angiotensin converting enzyme inhibitor (lisinopril)in type 1 diabetic patients with diabetic kidney disease. In total, 51 patients were randomised to treatment with one of these drugs for 4 years. Changes in kidney function, blood pressure and urinary excretion of albumin were measured every 6 months

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diabetic nephropathy, type 1 diabetes, hypertension

Exclusion criteria

• child bearing potential, non-diabetic kidney disease, malignancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind