Repair, Remodeling and Regeneration of the Bronchial Epithelium of COPD Patients (RRR)

University Hospital Center (CHU)

Status: Completed

Conditions: Smokers; COPD; Heathy Volunteers

Treatments: Other: In vitro experiments on bronchial epithelial cells

Study type: Interventional

Funder types: Other

Identifiers

NCT02354677

2013-A01405-40 (Other Identifier)

9244

Details and patient eligibility

About

COPD is characterized by exagerated decline FEV1 related to obstructive non reversible airflow. This could be the consequence of structural changes and inflammatory pattern of the bronchial wall. Lesions could lead to normal but also abnormal remodeling specially in COPD including a decrease in Club cells number and function.There is no treatment actually available targeted to a normal repair of the epithelium. The objective of this work is to identify potential targets for reprograming bronchial epithelial cells I order to achieve a good repair.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

COPD - Smokers or ex smokers > 30p/yr

• FEV1/FVC < 0.7
• With a fibroscopy prescription

Smokers - Smokers or ex smokers > 30p/yr

• FEV1/FVC > 0.7
• With a fibroscopy prescription

Controls - age superior or equal to 18

• no smoker (for 5 years)
• with a fibroscopy prescription

Exclusion criteria

• Xylocaine hypersensibility
• Porphyria
• severe hepatic failure
• Epilepsy
• Severe cardiac failure

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Heathy volunteers, smokers and COPD

Experimental group

Treatment:

Other: In vitro experiments on bronchial epithelial cells