Repeat Nasal Allergen Challenge

Imperial College London

Status and phase: Completed; Phase 2

Conditions: Hayfever

Treatments: Procedure: Nasal lavage; Procedure: Skin Prick Test; Procedure: Nasal scrape; Procedure: Nasal symptoms score; Procedure: Nasal filter paper placement; Procedure: Nasal allergen challenge

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00290368

CPJMR0052104

Details and patient eligibility

About

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.

Full description

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Male and female subjects with a history of seasonal (intermittent) atopic rhinitis, aged 18-40 years.
2. Otherwise healthy with no health problems that may jeopardize the subjects participating in the study, absence of history of other significant allergies.

Exclusion criteria

1. Smokers (use of tobacco products in the previous 3 months).
2. Presence of any respiratory disease other than a history of mild stable asthma not requiring treatment and associated with normal lung function (FEV1 > 80% predicted at screening).

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)