Repeating Patterns of Sleep Restriction and Recovery

Beth Israel Lahey Health

Status: Completed

Conditions: Healthy

Treatments: Behavioral: Control sleep; Behavioral: Repeated sleep restriction and recovery

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01523691

R01HL105544-01A1 (U.S. NIH Grant/Contract)

2010P000399

Details and patient eligibility

About

Goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems.

Enrollment: 17 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index (BMI) between 18.5 and 30 kg/m2
• For female participants: regular menstrual cycles
• Daily sleep duration in the normal range
• Blood chemistry in the normal range

Exclusion criteria

• Active infection/disease
• History of psychiatric, neurological, pain-related, immune, or cardiovascular disease; significant allergy
• Pregnant/nursing
• Respiratory disturbance index of >5 events/hour on polysomnographic sleep study, leg movements with arousal >10/hour; sleep efficiency <80%
• Regular medication use other than oral contraceptives
• Donation of blood or platelets 3 month prior to or in-between study arms

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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17 participants in 2 patient groups

repeated sleep restriction and recovery

Experimental group

Treatment:

Behavioral: Repeated sleep restriction and recovery

control sleep

Experimental group

Treatment:

Behavioral: Control sleep