Repetitive Transcranial Magnetic Stimulation as a Treatment for Tinnitus (rTMS)

Seoul National University logo

Seoul National University

Status

Unknown

Conditions

Tinnitus

Treatments

Device: Active rTMS 2
Device: sham condition
Device: Active rTMS 3
Device: Active rTMS 1

Study type

Interventional

Funder types

Other

Identifiers

NCT01886092
H-1212-081-451
SNUHT1 (Other Identifier)

Details and patient eligibility

About

Efficacy of different protocols of transcranial magnetic stimulation for the treatment of tinnitus

Full description

Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex has an add-on effect for primary auditory cortex rTMS in improving tinnitus-related distress. The investigators aimed to investigate whether rTMS of the dorsolateral prefrontal cortex and primary auditory cortex are capable of reducing tinnitus loudness.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Diagnosis of chronic tinnitus
  • Chronic subjective tinnitus for more than 6 months
  • Subject is naive regarding rTMS
  • Other concurrent treatments: A four-week washout from any other tinnitus treatment or management program is required prior to entering this study
  • Stable enough to complete this study per the opinion of the Study Physician
  • No restrictions, provided the dosages have been in place for at least 3 months
  • A three month washout from any other tinnitus treatment or management program is required prior to entering this study.

Exclusion criteria

  • Objective tinnitus or tinnitus with treatable cause
  • Presence of intracranial or intraocular ferromagnetic materiel or particles
  • Cardiac pacemaker or other electronic implants (including cochlear implant) Serious heart disease or other unstable major medical condition
  • Personal history of central nervous system disorder, head injury, stroke or seizures
  • Familial history of epilepsy
  • Concomitant medication with antidepressants and antipsychotics
  • Pregnant women
  • Others known contraindications to rTMS or brain MRI

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

80 participants in 4 patient groups

Active rTMS1
Active Comparator group
Description:
Combined low frequency frontal and temporal repetitive transcranial magnetic stimulation of left primary auditory cortex and left dorsolateral prefrontal cortex
Treatment:
Device: Active rTMS 1
Active rTMS2
Active Comparator group
Description:
Temporal low frequency repetitive transcranial magnetic stimulation of left primary auditory cortex
Treatment:
Device: Active rTMS 2
Active rTMS3
Active Comparator group
Description:
Frontal low frequency repetitive transcranial magnetic stimulation of left dorsolateral prefrontal cortex
Treatment:
Device: Active rTMS 3
Sham Condition
Sham Comparator group
Description:
Combined low frequency frontal and temporal repetitive transcranial magnetic stimulation of left primary auditory cortex and left dorsolateral prefrontal cortex
Treatment:
Device: sham condition

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems