Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

Shanghai Mental Health Center

Status: Unknown

Conditions: Tardive Dyskinesia

Treatments: Device: Repetitive Transcranial Magnetic Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02840760

15ZR1435600

Details and patient eligibility

About

The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.

Full description

The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical symptoms and MEP were assessment before and after rTMS treatment.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The diagnosis of schizophrenia according to DSM-IV；
• At least two item of Abnormal Involuntary Movement Scale（AIMS） must be 2 points or higher
• these symptoms are not from Parkinson，tourette's syndrome,huntington disease
• Signed an informed consent

Exclusion criteria

• rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure
• patients to be diagnosed according to DSM-IV for substance abused, development delayed
• current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines
• Acute risk of suicide and impulse
• history of epileptic seizures or the presence of epileptic activity documented on the basis of EEG
• pregnant and lactant women

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

tardive dyskinesia group

Active Comparator group

Description:

tardive dyskinesia group will be delivered at an intensity that is 80% of the resting motor threshold (RMT). Stimulation will be delivered at 10 Hz with 60 stimulation trains of 30 stimuli each (i.e., 1800 stimuli) and an intertrain interval of 12 sec in primary motor cortex（M1）.

Treatment:

Device: Repetitive Transcranial Magnetic Stimulation

Healthy control group

No Intervention group