Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive Compulsive Disorders (rTMS-OCD)

Assiut University

Status: Completed

Conditions: Obsessive Compulsive Disorders

Treatments: Procedure: rTMS-10 Hz; Procedure: rTMS-1Hz; Procedure: Sham rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT02511392

rTMS-OCD

Details and patient eligibility

About

Objectives.-Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive stimulation methods that became widely used as therapeutic tools in neuropsychiatric research. The aim of this study is to Evaluate the therapeutic impact of different frequencies of repetitive transcranial stimulation (1HZ, 10HZ) in OCD patients. Material and Methods; Forty five patients of OCD were participated in the study. All patients fulfilled the diagnostic criteria of DSM-IV-TR. The mean age of the patients was 27.1+4.5 years. Each patient was subjected to the following: Yale-Brown obsessive compulsive scale (Y-BOCS), Hamilton Anxiety Rating Scale (HAM-A), and Clinical Global Impression - Severity scale (CGI-S). The patients were randomly classified into three equal groups using closed envelop: 1st group received 1 Hz rTMS at 100% of the RMT, 2nd group received 10 Hz rTMS with intensity of 100% of the RMT and 3rd group was sham group received the sham stimulation with a total 2000 pulses every day for each group for 10 sessions. Follow up of the patients using the same previous scales after the end of sessions and 3 months later.

Enrollment: 45 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients fulfilled the diagnostic criteria of DSM-IV-TR

Exclusion criteria

• Patients with comorbid psychiatric disorder .

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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45 participants in 3 patient groups

Group 1: Real rTMS-1 Hz

Active Comparator group

Description:

Included 15 patients, they received 1 Hz rTMS with intensity of 100% of the RMT continuous with total 2000 applied in 200 trains, each of 10 pulses, with 5 seconds intertrain interval

Treatment:

Procedure: rTMS-1Hz

Group 2: Real rTMS-10 Hz

Active Comparator group

Description:

Included 15 patients, they received 10 Hz rTMS with intensity of 100% of the RMT applied in 10 trains, each of them 200 pulses, with 20 seconds intertrain interval

Treatment:

Procedure: rTMS-10 Hz

Group 3: Sham rTMS

Sham Comparator group

Description:

Included 15 patients; they received the same number of pulses 2000 pulse applied in 200 trains, each of 10 pulses, with 5 seconds intertrain interval, but coil was placed over the same area but perpendicular to the scalp.

Treatment:

Procedure: Sham rTMS