Repetitive Transcranial Magnetic Stimulation in Treatment and Prophylaxis of Chronic Migraine in Patients With no Prophylactic Treatment for the Last 3 Months (rTMS)

Sohag University

Status: Enrolling

Conditions: Chronic Migraine

Treatments: Device: transcranial magnetic stimulation device

Study type: Interventional

Funder types: Other

Identifiers

NCT06461767

Soh-Med-24-05-06MS

Details and patient eligibility

About

Compared with the patients with episodic migraine those with chronic migraine have worst quality of life and more severe headache related disability we investigate Repetitive transcranial magnetic stimulation in treatment and prophylaxis of chronic migraine

Enrollment: 60 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• A study sample of patients with chronic migraine according to international classification of headache disorders-3 (ICHD-3).
• Patients are regular on follow up visits.

Exclusion criteria

• Patients with depression by Hamiliton scale of depression by using its Arabic version Translated by Dr Lotfy Fateem
• patients on prophylactic medications for chronic migraine.
• pregnancy.
• cochlear implants, cardiac pacemaker, and metal body implanted in head-and-neck region.
• Patients refused to give informed consent.
• History of seizures.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 4 patient groups

group (1) will rTMS over left motor cortex

Active Comparator group

Description:

Repetitive transcranial magnetic stimulation parameters: stimulation site: left motor cortex intensity: 70% of resting motor threshold frequency: 15 Hz number of pulses: 30 number of trains: 40

Treatment:

Device: transcranial magnetic stimulation device

group (2) will receive rTMS over left dorsolateral prefrontal cortex

Active Comparator group

Description:

Repetitive transcranial magnetic stimulation parameters: stimulation site: left dorsolateral prefrontal cortex intensity: 70% of resting motor threshold frequency: 15 Hz number of pulses: 30 number of trains: 40

Treatment:

Device: transcranial magnetic stimulation device

group (3) will receive rTMS over left dorsolateral prefrontal cortex and left motor cortex

Active Comparator group

Description:

Repetitive transcranial magnetic stimulation parameters: stimulation site: left dorsolateral prefrontal cortex and left motor cortex intensity: 70% of resting motor threshold frequency: 15 Hz number of pulses: 30 number of trains: 40

Treatment:

Device: transcranial magnetic stimulation device

group (4) will receive sham stimulation

Sham Comparator group

Description:

Repetitive transcranial magnetic stimulation parameters: stimulation site: the coil will be perpendicular over vertex of skull intensity: 70% of resting motor threshold frequency: 15 Hz number of pulses: 30 number of trains: 40

Treatment:

Device: transcranial magnetic stimulation device