Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome (rTMSPPCGT)

Institut National de la Santé Et de la Recherche Médicale, France

Status and phase

Terminated

Phase 2

Conditions

Gilles de la Tourette Syndrome

Tics

Treatments

Device: rTMS

Device: Sham rTMS

Study type

Interventional

Funder types

Other

Identifiers

NCT01043549

2009-A00759-48 (Registry Identifier)

C08-46

Details and patient eligibility

About

Repetitive transcranial stimulation (rTMS) of the posterior parietal cortex will be applied daily over five days in adult Gilles de la Tourette patients. This approach aims at reducing premonitory sensations believed to induce tics. Patients will be randomized to an active or placebo (sham) group in a crossover design.

Enrollment

5 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Gilles de la Tourette syndrome as defined by DSM IV-R
Yale Global Tics Severity Scale (YGTSS) score between 30 et 60
Premonitory sensations (" urge to move ")
Affiliated to the French social security regime
Ability to give informed consent

Exclusion criteria

rTMS : epilepsy, craniotomy scar, pacemaker or neural stimulator, metal implants or foreign bodies, claustrophobia, pregnancy
Cognitive impairment (MMS ≤ 24/30)
Axis I disorders according to DSM IV-R : psychosis or history of psychosis, bipolar illness, major depressive disorder, addictions (except to nicotine)
Impulse control disorders
Other chronic debilitating illnesses
Unability to give informed consent
Participation in another clinical trial