Repetitive Transcranial Magnetic Stimulation Therapy in Essential Tremor (rTMS)

Soochow University

Status: Enrolling

Conditions: Essential Tremor

Treatments: Device: real rTMS; Device: sham rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT06145932

JD-LK2023096-IR01

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy and electrophysiology of repetitive transcranial magnetic stimulation in the treatment of essential tremor.

Full description

This is a randomized controlled study.The purpose is to evaluate the efficacy of repetitive transcranial magnetic stimulation(rTMS) in the treatment of essential tremor,and explore the possible mechanism by detecting the changes of clinical scale and TMS-electroencephalogram(TMS-EEG), so as to seek an effective therapy for essential tremor.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosed as essential tremor conforming to the diagnostic criteria for essential tremor in the tremor group of the International Parkinson's and Movement Disorders Society (IPMDS).
2. Signed informed consent form.

Exclusion criteria

1. Complicated with brain organic diseases, epilepsy, other mental diseases, family history of dementia, metal devices implanted in the body and any contraindications to TMS;
2. History of craniocerebral surgery;
3. TMS cannot cooperate;
4. TMS-EEG examination artifacts are obvious, or cannot be analyzed due to other technical reasons.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

rTMS treatment group

Experimental group

Description:

treated with real rTMS 1800 pulses / day,for 10 days

Treatment:

Device: real rTMS

Sham rTMS treatment group

Sham Comparator group

Description:

treated with sham rTMS 1800 pulses / day,for 10 days

Treatment:

Device: sham rTMS