Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System (LSFG Repro)

University of Zurich (UZH)

Status: Completed

Conditions: Healthy; Open Angle Glaucoma; Normal Tension Glaucoma

Treatments: Diagnostic Test: LASER SPECKLE FLOWGRAPHY

Study type: Observational

Funder types: Other

Identifiers

NCT04014933

LSFG Repro

Details and patient eligibility

About

In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.

Full description

According to the World Health Organization (WHO) glaucoma is the second leading cause of blindness. Glaucoma is a global problem, which is becoming even more important as the human life expectancy increases. Although the causes of glaucoma are uncertain, mainly intraocular pression (IOP), genetics, and ocular blood perfusion pressure in the optic nerve determine the cause of the disease. Increasing evidence suggests that in glaucoma patients retinal blood flow is decreased leading to progression and to damage of the optic nerve.

In order to measure the peripapillary blood flow a variety of devices using different techniques of flowmetry have been developed. In this study, the reproducibility of the retinal flowmetry measured with the LSFG-NAVI device from Nidek will be investigated. A high reproducibility is crucial for the clinical value of any measuring device.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• signed Patient Informed Consent form
• Be at least 18 years old
• Diagnosis of primary or secondary open-angle glaucoma or normal tension glaucoma or healthy controls

Exclusion criteria

• Age < 18 years
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.
• No vulnerable participants will be included in this study.

Trial design

44 participants in 3 patient groups

open-angle glaucoma

Description:

patients with a diagnosis of open-angle glaucoma, i.e. untreated IOP \>21mmHg plus glaucomatous disc changes and/or visual field defects typical for glaucoma

Treatment:

Diagnostic Test: LASER SPECKLE FLOWGRAPHY

normal tension glaucoma

Description:

patients with a diagnosis of normal tension glaucoma, i.e. untreated IOP \</=21mmHg plus glaucomatous disc changes and/or visual field defects typical for glaucoma

Treatment:

Diagnostic Test: LASER SPECKLE FLOWGRAPHY

healthy controls

Description:

individuals with normal optic disc and IOP \</21mmHg and normal visual fields

Treatment:

Diagnostic Test: LASER SPECKLE FLOWGRAPHY