Requirement of Analgesics After Two Remifentanil Dosing Regimen in Cardiac Surgery. (REMISYD)

Kuopio University Hospital

Status and phase: Completed; Phase 4

Conditions: Pain

Treatments: Drug: remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT00757198

KUH5070206

EudraCT 2008-000597-21

Details and patient eligibility

About

Prospective double blind study comparing two remifentanil dosing protocols (0.1 and 0.3 mcg/kg/min) during cardiac surgery. Main outcome measures are postoperative opioid requirements (PCA oxycodone) and postoperative pain (VAS, verbal rating scale).

Enrollment: 90 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Coronary artery bypass grafting patients

Exclusion criteria

• Psychiatric disorders, sleep apnea, cardiac insufficiency

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 2 patient groups

1

Experimental group

Description:

remifentanil o.1 mcg/kg/min

Treatment:

Drug: remifentanil

Drug: remifentanil

2

Active Comparator group

Description:

remifentanil 0.3 mcg/kg/min

Treatment:

Drug: remifentanil

Drug: remifentanil