Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease

Naval Military Medical University

Status: Completed

Conditions: Parkinson's Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01998204

Parkinson-propofol

Details and patient eligibility

About

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.

Enrollment: 62 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia
• non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia

Exclusion criteria

• ASA score higher than Class III
• predicted difficult airway
• hearing impairment
• inability to corporate with instruction
• alcohol or drug abuser
• patients refusing to provide informed consent

Trial design

62 participants in 2 patient groups

PD group

Description:

Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement

non-PD group

Description:

Patients without Parkinson's disease undergoing intracranial surgery