Rescue Quadratus Lumborum Blocks for Post-cesarean Pain

The University of Texas System (UT)

Status and phase: Withdrawn; Phase 4

Conditions: Analgesics; Morphine; Peripheral Nervous System Agents; Analgesics, Opioid

Treatments: Drug: Dexamethasone; Drug: Saline; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT04397458

HSC-MS-20-0124

Details and patient eligibility

About

The purpose of this study is to assess whether quadratus lumborum (QL) block performed 1 day after cesarean delivery will provide supplemental post-cesarean analgesia and reduce opioid requirements.

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective or non-elective cesarean delivery on prior day
• pain scores >5/10

Exclusion criteria

• BMI >40
• obstructive sleep apnea
• drug abuse
• chronic pain
• chronic opioid use
• abdominal surgeries other than cesarean delivery
• contraindications to neuraxial or regional anesthesia
• received general anesthesia or did not receive neuraxial morphine for cesarean delivery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

Sham Control

Sham Comparator group

Description:

20 milliliters (mL) 0.9% saline on each side

Treatment:

Drug: Saline

Quadratus Lumborum Block

Experimental group

Description:

20 mL solution with 0.25% bupivacaine (50 milligrams (mg)) and 3mg preservative-free dexamethasone on each side

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine