Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout

Zhejiang University

Status: Unknown

Conditions: Uric Acid; Gut Microbiota; Hyperuricemia; Genetic Loci; Feces; Single Nucleotide Polymorphism; Gout

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04953533

2020C03044

Details and patient eligibility

About

To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.

Full description

1. To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.
2. to measure the level of uric acid in feces.

Enrollment: 800 estimated patients

Sex: Male

Ages: 25 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

gout

Inclusion Criteria:

1. age:year of 25~60;
2. Be consistent with the 2015 American College of Rheumatology/ European League Against Rheumatism (ACR/EULAR) gout diagnostic criteria ,and serum uric acid >420 μmol/L;
3. The patient are willing to take part in our study.

Exclusion Criteria:

1. abronia, surgery, postoperative, dehydration within 2 weeks, acute or chronic infectious diseases, severe trauma, malnutrition, diabetes, malignant tumors;
2. diagnosed as cardiovascular and cerebrovascular diseases within 3 months;
3. heart failure (New York Heart Academy，grade IV);
4. hepatic insufficiency ( Alanine transaminase or Aspartate aminotransferase ≥3×upper limit)；
5. chronic kidney disease or abnormal renal function( serum creatinine ≥1.5×upper limit)；
6. excessive drinking；
7. The investigators considered the patients unsuitable for inclusion in this study.

hyperuricemia:

Inclusion Criteria:

1. age:year of 25~60;
2. A medical record in our hospital showed that the person is healthy, without key disease;
3. serum uric acid >420μmol/L without gout flares. Exclusion Criteria:Same as the group of gout.

healthy controls:

Inclusion Criteria:

age:year of 25~60; A medical record in our hospital showed that the person is healthy, without key disease; serum uric acid ≤420μmol/L. Exclusion Criteria:Same as the group of gout.

Trial design

800 participants in 3 patient groups

patients with gout

Description:

1. age:year of 25\~60; 2. consistent with the 2015 ACR gout diagnostic criteria ,and serum uric acid \>420umol/L; 3. The patient are willing to take part in our study.

Treatment:

Other: no intervention

patients with hyperuricemia

Description:

1. age:year of 25\~60; 2. A medical record in our hospital showed that the person is healthy, without key disease; 3. serum uric acid \>420umol/L without gout flares.

Treatment:

Other: no intervention

healthy controls

Description:

1. age:year of 25\~60; 2. A medical record in our hospital showed that the person is healthy, without key disease; 3. serum uric acid ≤420umol/L.

Treatment:

Other: no intervention