Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis

Lin Jiacheng

Status: Unknown

Conditions: Periapical Diseases

Treatments: Drug: creosote; Drug: Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste

Study type: Interventional

Funder types: Other

Identifiers

NCT02196740

Tri-antibiotic-2014

Details and patient eligibility

About

The triple antibiotic paste is widely used in young permanent teeth and permanent teeth root canal therapy with excellent antiantimicrobial effect.We hypothesize that its application in the treatment of periapical periodontitis of deciduous teeth is superior to other drugs currently in use as creosote.

Full description

We design to collect a group of patients presenting primary teeth with periapical periodontitis in certain criterion. We will divide the patients into two groups randomly.One group will get treated with triple antibiotic paste while the other with creosote.We want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of triple antibiotic paste.

Enrollment: 100 estimated patients

Sex: All

Ages: 3 to 8 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of periapical periodontitis
• must be primary teeth
• must be 3~8 years old
• the permanent tooth germ is complete and didnot be involved

Exclusion criteria

• blood disease
• residual root that is advised to extract
• serious periodontitis
• allergy to the triple antibiotic paste

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

creosote

Active Comparator group

Description:

Creosote ，once，three weeks Triple Antibiotic Paste ，none

Treatment:

Drug: creosote

Triple Antibiotic Paste

Experimental group

Description:

Triple Antibiotic Paste,once,three weeks creosote,none

Treatment:

Drug: Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste