Research on Association Between Selenium Deficiencies and Change of Thyroid Function

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Selenium Deficiency

Treatments: Diagnostic Test: detection of serum selenium

Study type: Observational

Funder types: Other

Identifiers

NCT03448588

Liuyanping3

Details and patient eligibility

About

As one of the essential micronutrients, selenium has important biological functions. However, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. Previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( T4) to triiodothyronine (T3). A case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated T4 or T4/T3, which may provide more clues for establishing effective selenium assesment methods.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• with normal free triiodothyronine( FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH).
• without thyroid hormone replacement therapy
• without medical history of thyroid surgery
• without iodine radiotherapy;

Exclusion criteria

• acute critical illness in the latest 1 year;
• weight fluctuation by more than 5% in the latest 3 months;
• eating disorders
• neuropsychological disorders
• allergy to corn or yeast
• fail to give informed consents.

Trial design

200 participants in 2 patient groups

group with normal T4 level or T4/T3

Description:

participants with T4 within 4.3-12.5ug/dl and ratio of T4/T3(T4(ug/dl)/T3 (ng/ml)) ≤7.52, which are considered to be normal T4 level and T4/T3.

Treatment:

Diagnostic Test: detection of serum selenium

group with elevated T4 level or T4/T3

Description:

participants with T4 more than 12.5ug/dl and ratio of T4/T3(T4(ug/dl)/T3 (ng/ml)) \> 7.52, which are considered to be elevated T4 level and T4/T3.

Treatment:

Diagnostic Test: detection of serum selenium