Research on the Application and Mechanism of New Biological Probes in Biomedicine

Nanfang Hospital, Southern Medical University

Status: Completed

Conditions: Metabolic Diseases; Tumors; Infectious Diseases; Urinary System Diseases; Immune System Diseases; Digestive System Diseases; Nervous System Diseases; Cardiovascular Diseases; Respiratory System Diseases; Endocrine System Diseases; Blood Diseases

Treatments: Diagnostic Test: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04977739

NFEC-2021-007

Details and patient eligibility

About

Fluorescence is one of the most commonly used research and detection techniques in the field of biomedical science. The characteristics of fluorescent probe directly affect the performance and application of fluorescence analysis and imaging. Aggregation-Caused Quenching has limited the application of traditional fluorescent probes to some extent. This project intends to systematically evaluate the detection efficiency of new methods through the detection of biomarkers in clinical samples and the comparison with the detection methods of traditional biomarkers, so as to provide theoretical and experimental basis for the establishment of fast and simple biomarker detection technologies with new biological probes.

Enrollment: 737 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sign the informed consent form voluntarily.
• Age 18-70 years old.
• High expression (positive) group: The results of multiple laboratory tests indicate that the marker is higher than the normal range.
• Low expression (negative) healthy volunteer group: those with no underlying diseases and no abnormalities in the physical examination.
• Have routine examination to check the remaining body fluid samples, and the body fluid samples are not contaminated.

Exclusion criteria

• Accompanied by other inflammations.
• The data of the subject is not complete, or the collection of cases is incomplete due to other reasons.
• The researcher judged that it was not suitable to participate in this research.

Trial design

737 participants in 2 patient groups

those with a condition

Treatment:

Diagnostic Test: No intervention

those without a condition

Treatment:

Diagnostic Test: No intervention