Research on the Clinical Effect of Effective Prescription in Treating Unstable Angina.

Jun Li

Status and phase: Unknown; Phase 4

Conditions: Unstable Angina

Treatments: Drug: Anti-Platelet Drugs; Drug: Lipid Regulating Drugs; Drug: Coronary Vasodilator; Drug: Xuefu Zhuyu Decoction; Drug: Shuanghe Decoction; Drug: Gualou Xiebai Banxia Decoction & Danshen Decoction

Study type: Interventional

Funder types: Other

Identifiers

NCT03171597

YXFJ-2017

Details and patient eligibility

About

This study evaluates the clinical efficacy of the famous prescription in the treatment of unstable angina pectoris. All of the patients will be divided into 4 arms according to their syndrome type. One of the arms will be treated by conventional western medicine, the other three will be treated by different Chinese herbal medicine prescription at the base of conventional western medicine.

Full description

Xuefu Zhuyu Decoction has the function of activating qi and promoting blood circulation, which will be used to treat patients with qi stagnation and blood stasis syndrome.

GualouXiebaiBanxia Decoction compounded with Danshen Decoction has the effect of promoting blood circulation and resolving phlegm, so it will be used for patients taht belong to phlegm and blood stasis type.

Shuanghe Decoction has the function of supplementing Qi and activating blood circulation, which will be used to treat patients with Qi deficiency and blood stasis syndrome.

Enrollment: 240 estimated patients

Sex: All

Ages: 35 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants diagnosed with coronary heart disease through coronary angiography or coronary CTA;

Patients have at least one of these symptoms:

1. The stability of the nature of angina pectoris changes, that is, frequent attacks of angina pectoris, serious degree and prolonged duration;
2. Angina pectoris during rest;
3. The recent occurrence of angina pectoris caused by mild physical activity in the last month.

Exclusion criteria

• Patients dignosed with stable angina; Patients with acute myocardial infarction; Chest pain caused by congenital heart disease, valvular heart disease, severe neurosis or arrhythmia; The heart function grade is III or IV; Patients with acute cerebral infarction; Patients complicated with other serious primary diseases; Patients with acute infection in recent 2 weeks; Uncontrolled hypertension (the resting blood pressure >160/95mmHg within one week); Diabetics emerged with serious diabetic complications; Patients can't finish the questionnaire due to abnormal mental and nervous or mental disorders; Pregnant or lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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240 participants in 4 patient groups

conventional western medicine

Other group

Description:

Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc.

Treatment:

Drug: Lipid Regulating Drugs

Drug: Anti-Platelet Drugs

Drug: Coronary Vasodilator

Qi deficiency and blood stasis

Experimental group

Description:

Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine.

Treatment:

Drug: Lipid Regulating Drugs

Drug: Anti-Platelet Drugs

Drug: Coronary Vasodilator

Drug: Shuanghe Decoction

Qi stagnation and blood stasis

Experimental group

Description:

Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine.

Treatment:

Drug: Xuefu Zhuyu Decoction

Drug: Lipid Regulating Drugs

Drug: Anti-Platelet Drugs

Drug: Coronary Vasodilator

Phlegm and blood stasis

Experimental group

Description:

Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine.

Treatment:

Drug: Lipid Regulating Drugs

Drug: Anti-Platelet Drugs

Drug: Coronary Vasodilator

Drug: Gualou Xiebai Banxia Decoction & Danshen Decoction