Research on the Relationship Between Cognitive Function Changes and Cerebrovascular Health in Patients With Coronary Heart Disease

Nanjing University of Traditional Chinese Medicine

Status

Not yet enrolling

Conditions

Coronary Heart Disease

Image

Treatments

Device: magnetic resonance image

Diagnostic Test: Neuropsychological scale

Study type

Observational

Funder types

Other

Identifiers

NCT05848934

82071993-1

Details and patient eligibility

About

The purpose of this study is to elucidate the imaging mechanisms of cognitive function changes in patients with coronary heart disease before and after surgery or conservative treatment, and to evaluate and predict the postoperative neurological function recovery and cerebrovascular health level of patients by combining serum markers and patient cardiovascular health evaluation indicators.

Full description

The focus of this study is to elucidate the impact of coronary heart disease on the morphology and cognitive changes of cerebral blood vessels in patients. Record imaging data, neuropsychological cognitive scales, serum markers, adverse cardiac events, and patient evaluation indicators before and after clinical treatment and follow-up period, and explore relevant factors affecting changes in cerebrovascular morphology and cognitive function.

Enrollment

100 estimated patients

Sex

All

Ages

40 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Confirmed coronary heart disease or risk of coronary heart disease through clinical testing
Conscious and capable of completing neuropsychological scales

Exclusion criteria

Patients with other serious heart diseases (such as aortic aneurysm)
People with uncontrolled hypertension or diabetes
There are contraindications to MRI examination (there are metal implants in the body, such as cardiac pacemakers, metal dentures, artificial joints, non paramagnetism stents, etc.; there is claustrophobia)
Have a history of severe stroke, epilepsy, traumatic brain injury, and transient ischemic events
Existence of neurological and mental disorders (schizophrenia, depression, etc.), post-traumatic stress disorder, obsessive-compulsive disorder, multiple sclerosis, amyotrophic lateral sclerosis, etc
Have a history of alcohol or drug abuse
Those with significant organ dysfunction such as lung, liver, and kidney;
Patients with tumor, infectious diseases, blood system disease and immune system disease;
Currently participating in other clinical studies at the same time.