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This study is being done to answer the following question: Will aerobic exercise (exercise that stimulates and strengthens the heart and lungs, and improves the body's use of oxygen) change the biomarkers (signs of disease) found in the blood?
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Inclusion criteria
Cohort 1: CH
CH called by MSK practices as documented by an MSK physician
Age ≥18 yrs
Completion of all anticancer therapy
High risk of cardiovascular disease defined by presence of at least one of the following:
Performing less than 150 minutes of structured moderate-intensity or strenuous-intensity exercise per week, as evaluated by self-report
Willingness to comply with all study-related procedures
Cohort 2: Solid Tumor
Patients at risk of harboring circulating tumor DNA as defined by one of the following:
Age ≥ 18 yrs
Performing less than 150 minutes of structured moderate-intensity or strenuous-intensity exercise per week, as evaluated by self-report
Willingness to comply with all study-related procedures
Cohort 3: Active Surveillance
Cohort 4: Lynch Syndrome
Cohort 5: EDD Phase 0a
Phase 0b
Exclusion criteria
Concurrent use of any form of antitumor therapy (endocrine therapy and anti-HER2 antibodies allowed)
Enrollment onto any other interventional investigational study except interventions determined by the PI not to confound study outcomes (does not apply to Cohort 5: EDD)
Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation.
Mental impairment leading to inability to cooperate
Any of the following contraindications to cardiopulmonary exercise testing (Cohorts 1 and 2 only):
Room air desaturation at rest ≤ 85% (Cohorts 1 and 2 only)
Primary purpose
Allocation
Interventional model
Masking
52 participants in 5 patient groups
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Central trial contact
Lee Jones, PhD; Jessica Scott, PhD
Data sourced from clinicaltrials.gov
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