Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators (REST)

Beth Israel Lahey Health

Status: Enrolling

Conditions: Cognitive Change; Sleep Deprivation; Sleep

Treatments: Behavioral: Shoonya Meditation; Behavioral: Nap Practitioners

Study type: Interventional

Funder types: Other

Identifiers

NCT05026541

2021P000544

Details and patient eligibility

About

This study aims to investigate the effect of a 15-minute meditation practice on sleep architecture and high-frequency Heart Rate Variability (HF-HRV), as well as cognitive performance after both a well-rested and sleep-deprived night.

Full description

Sleep is physiologically important for memory consolidation, mood and hormonal regulation, and maintaining low levels of systemic inflammation. However, a substantial proportion of people are reported to regularly sleep less than the recommended 7-9 hours a night. Meditation may be a means to mitigate the negative effects of sleep deprivation, as many types of meditations are associated with increasing high-frequency heart rate variability (HF-HRV), which is an index of parasympathetic control of the heart. Greater parasympathetic drive may be associated with physiological buffering of the detrimental effects of sleep deprivation.

The investigators want to conduct a prospective cohort study where subjects are asked to learn and practice a 15-minute meditation (shoonya meditation) or continue their usual routine. Subjects will be asked to complete some cognitive tests before and after a night of sleep and a night of sleep deprivation. During the night of sleep, participants will undergo polysomnography recording for sleep architecture and quality.

The intervention group will be asked to undergo these same study procedures after 2 months of meditation practice. The control group, which continues their usual routine, will only undergo one visit.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Shoonya meditation program participants/individuals eligible to participate who are healthy adults of age 18 or older, and reside in the United States. Participants must be able and willing to travel to Boston.
2. Nap Group: Healthy adults of age 18 or older that reside in the United States, nap regularly (at least 3 times a week), and do not meditate regularly.

Exclusion criteria

1. History of any neurological condition (i.e. Parkinson's disease, Alzheimer's disease, Huntington's disease, brain tumors, brain surgery, or multiple sclerosis)
2. History of any psychiatric disorder, within last 5 years (i.e. anxiety, psychosis, posttraumatic stress disorder, attention deficit hyperactive disorder)
3. Current use of cognition enhancing medications
4. Active history (within the last 5 years) of alcohol or drug abuse (> 10 drinks per week)
5. History (within the last 5 years) of stroke/aneurysm
6. Recent history (< 3 months) of seizures
7. 60 years of age or older
8. History of Heart Attack and Ejection Fraction less than or equal to 30%
9. Pregnancy
10. Non-English speaking
11. History/Diagnosis of any sleep disorder
12. Consumption of 3 or more cups of coffee a day
13. Previously learned shoonya meditation (for the meditator groups)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

60 participants in 3 patient groups

Nap Practitioners

Sham Comparator group

Description:

This is an observational arm of regular nappers. Individuals that take naps at least two times a week will be invited to undergo all of the study procedures for one weekend of data collection.

Treatment:

Behavioral: Nap Practitioners

Shoonya Meditators

Active Comparator group

Description:

This is intervention arm. Participants will learn and practice the fifteen minute shoonya meditation - described as a process of conscious non-doing- and shakti chalana kriya, which is a set of breathing exercises designed as a preparatory practice to shoonya meditation. Participants will practice shoonya meditation twice a day for two months. A weekend of data collection will happen at baseline and two months after they learn the practice.

Treatment:

Behavioral: Shoonya Meditation

Control Meditators

No Intervention group

Description:

Control subjects will be individuals that have learned the prerequisite meditation to Shoonya meditation. This meditation is called Shambhavi Mahamudra Kriya. Control subjects will not learn Shoonya meditation while they are participating in the study. One weekend of data collection will occur at baseline.