Resistance Characteristics and Development of Diagnostic Model for Postoperative UTI in Patients With Kidney Stones

Xingxin Jiang

Status: Completed

Conditions: Antimicrobial Resistance; Kidney Stones; Urinary Tract Infection Complicated

Treatments: Other: the UTI group; Other: the Non-UTI group

Study type: Observational

Funder types: Other

Identifiers

NCT06946667

No. 2025-008

Details and patient eligibility

About

The combined detection of HBP, ADPN, NGAL, and hs-CRP enables the construction of a highly efficient diagnostic model, offering a novel strategy for early infection identification and risk stratification after surgery.

Full description

This study investigated pathogen distribution, antimicrobial resistance, and the diagnostic utility of biomarkers (hs-CRP, HBP, NGAL, ADPN) for Urinary Tract Infections (UTI) after kidney stone surgery. A total of 130 patients with kidney stones, treated between February 2021 and December 2024, were included in this study. Based on the occurrence of postoperative UTIs, they were categorized into the UTI group (n=41) and the Non-UTI group (n=89). Laboratory parameters, including WBC, NLR, NEU, hs-CRP, HBP, NGAL, and ADPN levels, were measured. Midstream clean-catch urine samples from patients in the UTI group were collected for pathogen identification and antimicrobial susceptibility testing. Pearson correlation analysis was performed to assess the relationships among these biomarkers, ROC curve analysis was conducted to evaluate diagnostic performance, and logistic regression analysis was used to identify independent risk factors for postoperative infections.

Enrollment: 130 patients

Sex: All

Ages: 44 to 62 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥18 years;
2. Diagnosis of urinary calculi confirmed by CT, X-ray, or ultrasound;
3. Complete clinical data available. -

Exclusion criteria

1. Presence of active UTI or other infections prior to surgery;
2. Coexisting urological disorders (e.g., bladder cancer, neurogenic bladder);
3. Prolonged use of immunosuppressants or antibiotics (>2 weeks). -

Trial design

130 participants in 2 patient groups

the UTI group

Description:

Midstream clean-catch urine samples from patients in the UTI group were collected for pathogen identification and antimicrobial susceptibility testing.

Treatment:

Other: the UTI group

the Non-UTI group

Description:

Midstream clean-catch urine samples from patients in the UTI group were collected for pathogen identification and antimicrobial susceptibility testing.

Treatment:

Other: the Non-UTI group