Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover

University of Florida

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Other: normal activities and clinical care; Other: Eccentric Focused Resistance Exercise; Other: Concentric Focused Resistance Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01245283

614-2009

Details and patient eligibility

About

The purpose of this study is to determine if a 4 month resistance exercise program can reduce knee osteoarthritis pain functional impairment and cartilage turnover.

Enrollment: 90 patients

Sex: All

Ages: 60 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Osteoarthritis (OA) of the knee for >6 months
• moderate to severe pain immediately following a 50-foot walk
• knee pain primarily due to tibiofemoral OA and not from patellofemoral OA
• bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee
• willing and able to participate in regular exercise for four months
• free from musculoskeletal limitations that would preclude resistance exercise participation
• free of abnormal cardiovascular responses during the screening graded maximal walk test

Exclusion criteria

• unable to walk
• regular resistance exercise training (>3X week) within the past 6 months
• specific low back pain or acute back injury
• spinal stenosis that precludes walking one block due to neurogenic claudication
• any major injury to either knee within the prior 12 months
• any surgery to either knee within the last 12 months
• lumbar radiculopathy
• vascular claudication
• significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee
• have had corticosteroid or viscosupplement injections within three months of study participation
• have added new over the counter or prescription pain medication within two months of study participation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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90 participants in 3 patient groups

Wait-list Non-exercise Control (CON)

Active Comparator group

Description:

Subjects will continue to participate in their normal activities and clinical care during the four month study period if assigned to this group.

Treatment:

Other: normal activities and clinical care

Concentric Focused RX (CRX)

Active Comparator group

Description:

Training protocol for 1 set of each exercise will be completed - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.

Treatment:

Other: Concentric Focused Resistance Exercise

Eccentric Focused RX (ERX)

Active Comparator group

Description:

The Human Dynamics Laboratory features prototype equipment that increases resistance loads during the eccentric phase of the contraction while "assistance" is provided by the machine during the concentric phase. One set of each exercise - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.

Treatment:

Other: Eccentric Focused Resistance Exercise