Resistance Exercise and Sleep Quality by Chronotype (TRE-SLEEP)

Medipol University

Status: Not yet enrolling

Conditions: Health Behavior / Well-Being; Circadian Rhythm; Chronotype; Sleep Quality; Resistance Exercise; Sleep Disturbances; Physical Therapy

Treatments: Behavioral: Moderate-Intensity Resistance Exercise Program

Study type: Interventional

Funder types: Other

Identifiers

NCT07234812

E-10840098-202.3.02-1592

Details and patient eligibility

About

This study examines whether doing moderate resistance exercises in the morning can improve sleep quality and well-being in young adults. Participants with different daily activity patterns (morning or evening types) will take part in an 8-week online exercise program. The study will compare how exercise affects sleep, mood, and daily rhythm across these groups.

Full description

Disturbed sleep is a widespread issue that affects health, mood, and daily function. Chronotype-the natural tendency to be active earlier or later in the day-may influence how people respond to exercise as a tool for improving sleep.

This trial investigates the effects of an 8-week, moderate-intensity resistance exercise program performed in the morning, delivered through telerehabilitation.

Participants include healthy young adults with self-identified morning or evening chronotypes. The study will measure changes in sleep quality, psychological well-being, alignment of daily rhythms, and will explore whether men and women respond differently to the program..

By comparing outcomes between chronotypes, this research aims to clarify whether exercise benefits are shaped by biological preference for morning or evening activity, or whether improvements occur regardless of chronotype.

The central question is whether improvements occur equally across chronotypes, or if biological preference shapes the response to exercise.

Null Hypothesis (H0): Moderate-intensity morning resistance exercise will have no differential effect on sleep quality, mood, or circadian alignment between participants with morning and evening chronotypes.

Alternative Hypothesis (H1):Moderate-intensity morning resistance exercise will have a differential effect on sleep quality, mood, or circadian alignment between participants with morning and evening chronotypes.

Enrollment: 64 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 18 and 35 years
• Generally healthy, with mild to moderate sleep disturbance as categorized by the Pittsburgh Sleep Quality Index (PSQI)
• Body Mass Index (BMI) < 35 kg/m²
• No physical or organic limitations or diseases that would prevent participation in physical activity
• Non-smoker and non-alcoholic
• Caffeine consumption ≤ 2 cups per day (including coffee and energy drinks)
• Have not participated in more than 60 minutes/week of usual moderate-to-vigorous physical activity in the past 6 months, categorized as "moderate" on the International Physical Activity Questionnaire-Short Form (IPAQ-SF)
• No clinically diagnosed sleep apnea or other medical/psychiatric disorders responsible for sleep complaints
• Regular sleep schedule (no night shifts or transmeridian travel) in the 30 days prior to study enrollment
• Able to speak and write English

Exclusion criteria

• Current use of medications or psychotherapeutic drugs for insomnia or other psychiatric disorders
• Use of melatonin or other sleep aids in the past month
• Currently performing any aerobic or mind-body exercise classes (e.g., yoga, Pilates)
• Habitual daytime napping
• History of epilepsy or other convulsive disorders
• Pregnant individuals
• Habitual or recent use (within the past 30 days) of illegal drugs, psychotropic drugs, hypnotics, stimulants, or analgesics

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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64 participants in 2 patient groups

Morning Chronotype - Moderate-Intensity Resistance Exercise

Experimental group

Description:

Participants identified as morning chronotypes (Munich Chronotype Questionnaire) will complete an 8-week, moderate-intensity resistance exercise program delivered online. Sessions are held in the morning, three times per week, lasting \~45 minutes (5-min warm-up, 35-min resistance training, 5-min cool-down). Exercises include push-ups, wall sits, squats, resistance band presses and pulls, rows, superman holds, and planks. Intensity is guided by 1RM testing, perceived exertion scales, and 7 point Likert scale of muscle soreness.

Treatment:

Behavioral: Moderate-Intensity Resistance Exercise Program

Evening Chronotype - Moderate-Intensity Resistance Exercise

Experimental group

Description:

Participants identified as evening chronotypes (Munich Chronotype Questionnaire) will complete an 8-week, moderate-intensity resistance exercise program delivered online. Sessions are held in the morning, three times per week, lasting \~45 minutes (5-min warm-up, 35-min resistance training, 5-min cool-down). Exercises include push-ups, wall sits, squats, resistance band presses and pulls, rows, superman holds, and planks. Intensity is guided by 1RM testing, perceived exertion scales, and 7 point Likert scale of muscle soreness.

Treatment:

Behavioral: Moderate-Intensity Resistance Exercise Program