Resistance Exercise, Muscle Mass, Strength and Body Composition

University of Erlangen-Nürnberg Medical School

Status and phase: Completed; Phase 3

Conditions: Obesity; Sarcopenia

Treatments: Other: HIT-exercise, low repetition range; Other: HIT-exercise with protein; Other: Control; Other: HIT-exercise, high repetition range

Study type: Interventional

Funder types: Other

Identifiers

NCT01766791

Study-098 (Other Identifier)

PUSH-D-ER

Details and patient eligibility

About

A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies.

Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.

Enrollment: 120 patients

Sex: Male

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• males
• untrained (< 2 h exercise/week, < 1 h resistance exercise/week)
• 30-50 years old

Exclusion criteria

• medication/diseases affecting intervention or study endpoints
• history of intense resistance exercise (> 3 h/week during the last decade)
• very low physical capacity (< 100 Watt at ergometry)
• more than 2 weeks of absence during the interventional period
• contraindication related to MRI-assessment (i.e. magnetizable intracorporal artefacts)
• pathological changes of the heart
• inflammable diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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120 participants in 4 patient groups, including a placebo group

HIT-exercise, low repetition range

Experimental group

Description:

High Intensity Resistance Exercise Training, low repetition range, \> 75% 1 Repetition Maximum (1RM)

Treatment:

Other: HIT-exercise, low repetition range

HIT-exercise, high repetition range

Experimental group

Description:

High Intensity Resistance Exercise Training, high repetition range, 60 - \<75% 1RM

Treatment:

Other: HIT-exercise, high repetition range

HIT-exercise with protein

Experimental group

Description:

High Intensity Resistance Exercise Training with protein supplementation

Treatment:

Other: HIT-exercise with protein

Control

Placebo Comparator group

Description:

No physical exercise intervention

Treatment:

Other: Control