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Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults

Arizona State University (ASU) logo

Arizona State University (ASU)

Status

Completed

Conditions

Cognitive Change
LPS
Mood Disorders

Treatments

Dietary Supplement: Vinegar liquid
Dietary Supplement: vinegar pill

Study type

Interventional

Funder types

Other

Identifiers

NCT06437405
STUDY00019774

Details and patient eligibility

About

Given its capacity to stimulate exercise-induced neuroplasticity at lower doses compared to aerobic exercise, resistance exercise has become the top-recommended rehabilitation approach for individuals with neurocognitive impairments. Despite a large body of evidence supporting its application in the context of cognition, little work has been done to investigate the role of resistance exercise in modifying the structure and function of the microbiota-gut-brain axis. Likewise, despite a general understanding of the benefits of short chain fatty acids such as acetate for the gut-brain axis, the impact of exogenous acetic acid has not been sufficiently examined in the context of the intestinal barrier. While self-reported mood disturbance responds favorably to vinegar ingestion, it is currently unknown if these effects are also associated with changes in intestinal permeability.

Full description

Existing resistance exercise interventions have produced promising outcomes indicating favorable shifts in microbial composition, intestinal barrier integrity, and serum biomarkers of inflammation. These changes appear to be particularly pronounced in individuals experiencing greater enhancements in lean mass, implying a crucial role for the hypertrophic effects of the exercise protocol. Given the current knowledge surrounding age-related cognitive decline and the pathophysiology of neurological and psychiatric disorders, it seems that many of the mechanisms significantly influenced by resistance exercise could contribute to reducing the risk or, at the very least, delaying the onset of these conditions. Considering the observed neuroplastic and neuroprotective effects of resistance exercise on the brain, it is plausible to hypothesize that the mitigation of excessive intestinal permeability and subsequent neuroinflammation may further support overall brain function. Given the potential for vinegar to enhance these outcomes, investigating the combined effects of exercise and vinegar ingestion may provide valuable insights into how lifestyle interventions can effectively promote cognitive and mental health. Therefore, the purpose of this work is to assess whether the combination of resistance exercise and vinegar ingestion elicits more favorable shifts in gut barrier function, cognition, and mental health compared to resistance exercise alone. This investigation aims to demonstrate the potential efficacy of this integrated approach in fostering long-team health outcomes.

Enrollment

29 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. premenopausal (for those assigned female at birth)
  2. willing and able to participate in moderate to vigorous exercise as determined by the ACSM Health/Fitness Facility Preparticipation Screening Questionnaire
  3. sedentary (defined as a score <14 on the Godin-Shepard Leisure Time Physical Activity Questionnaire (GSLTQ))
  4. equipped with access to a complete gym
  5. available for all lab visits (at weeks 0, 3, 9, and 15)

Exclusion criteria

  1. antibiotic use within the past three months
  2. prebiotic, probiotic, or high-dose antioxidant supplementation within the past month
  3. regular engagement in moderate to vigorous exercise
  4. following a vegetarian diet
  5. presence of any medical/psychiatric disease
  6. presence of any gastrointestinal disorder such as irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, diverticulitis/diverticulosis, etc.
  7. actively pregnant or breastfeeding

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

29 participants in 2 patient groups, including a placebo group

Liquid vinegar
Experimental group
Description:
2 tablespoons of liquid apple cider vinegar (5% acidity) diluted in one cup of water twice daily with meals providing 1.5g acetic acid.
Treatment:
Dietary Supplement: Vinegar liquid
Vinegar pill
Placebo Comparator group
Description:
one apple cider vinegar tablet (0.022g acetic acid) daily.
Treatment:
Dietary Supplement: vinegar pill

Trial contacts and locations

1

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Central trial contact

Carol Johnston, PhD

Data sourced from clinicaltrials.gov

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