Resistance Exercise Volume and Hypertrophic Response Variability in Elderly

University of Sao Paulo General Hospital

Status: Completed

Conditions: Aging; Muscle Hypertrophy

Treatments: Other: Lower body resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT06718712

62590416.0.0000.5391

Details and patient eligibility

About

The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).

Full description

The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.

Enrollment: 102 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 60 years and older
• not engaged in regular resistance and/or aerobic training for at least six months before the intervention

Exclusion criteria

• diagnosed type I diabetes mellitus
• arrhythmia
• noncontrolled hypertension
• any major orthopedic musculoskeletal condition
• use of any dietary supplement or drug with potential anabolic effects

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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102 participants in 2 patient groups

Single set

Experimental group

Description:

One set of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval.

Treatment:

Other: Lower body resistance training

Four sets

Experimental group

Description:

Four sets of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval between sets.

Treatment:

Other: Lower body resistance training