Resistance on Antithrombotic Drugs in Ischemic Heart Disease

University of Zagreb

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Procedure: PCI

Study type: Observational

Funder types: Other

Identifiers

NCT00742430

108-1081875-1993

Details and patient eligibility

About

The purpose of this study is to determine whether aspirin and clopidogrel resistance measured with Multiplate function analyser has a good correlation with incidence of major adverse cardiac events in patients with coronary artery disease (CAD).

Full description

Our plan is to enroll 180 patients with diagnosed CAD who electively undergo percutaneous coronary intervention (PCI). Blood samples will be taken just before the procedure and one day after the procedure and analysed on Multiplate function analyser. Assessing aspirin and clopidogrel resistance incidence using Multiplate platelet function analyzer we will also try to find resistance correlation with the incidence of major adverse cardiac events in a one year follow up.

Enrollment: 141 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective PCI
• > 7 days on aspirin 100mg therapy before the intervention
• > 7 days on clopidogrel 75mg therapy before the intervention

Exclusion criteria

• Loading dose of clopidogrel
• < 7 days on aspirin therapy before the intervention
• Myocardial infarction less than 30 days before the intervention
• Cerebrovascular incident less that three months before the intervention
• Haemorrhagic diathesis
• Trc < 100
• Htc < 30%
• Creatinine > 140

Trial design

141 participants in 2 patient groups

Resistant

Description:

patients who are resistant to standard antithrombotic drugs

Treatment:

Procedure: PCI

Nonresistant

Description:

patients who are not resistant to standard dual antithrombotic drugs

Treatment:

Procedure: PCI