Resistance Under the Microscope
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The purpose of this study is to determine whether lorazepam, which is used to lower preoperative anxiety, also improves postoperative recovery.
This study data will also be used for further research aiming to identify vulnerable patients in the day-case surgery setting.
Full description
Since the early 1980s, the investigators have seen a shift towards day-case surgery. Before surgery, many patients have negative feelings about the surgical procedure. These anxieties have various negative effects. To reduce this resistance preoperative administration of an anxiolytic drug is administered, typically a benzodiazepine. The investigators know that benzodiazepines are effective in reducing anxiety, but up to now there is nog good scientific evidence about the effectiveness of lorazepam on the quality of recovery in day-case surgery patients.
The ultimate goal of our research project is to identify patients who would benefit from preoperative benzodiazepine administration and who not. Identification would substantially contribute to optimal medical decision making.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- patients > 18 years admitted to the Day-Case Surgery Department Erasmus MC
Exclusion criteria
- insufficient command of the Dutch language
- ophthalmology surgery
- Extracorporeal Shock Wave Lithotripsy (ESWL)-, Gastrointestinal endoscopic intervention, Botox-, Abortion and Pain treatment
- Use of psychopharmaceuticals
- Contra-indication of lorazepam use
Trial design
Primary purpose
Allocation
Interventional model
Masking
400 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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