Resistant Arterial Hypertension Cohort Study (RAHyCo)

University Hospitals (UH)

Status: Completed

Conditions: Hypertension; Resistant Hypertension; Essential Hypertension

Treatments: Drug: chlorthalidone; Behavioral: motivational intervention for non-compliant individuals; Drug: standardized anti-hypertensive treatment

Study type: Observational

Funder types: Other

Identifiers

NCT01083017

CER09-237 (Other Identifier)

33CM30-124087 (Other Grant/Funding Number)

RAHyCOstudy

Details and patient eligibility

About

The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.

Enrollment: 74 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• informed consent
• resistant hypertension at the moment of inclusion
• 18 years or more, both sexes are included
• women at reproductive age: consenting to use oral contraception

Exclusion criteria

• patients mentally impaired or unable to give informed consent
• patients speaking only a foreign language other than French, German, or English
• patients living far away, making the study visits not practical

Trial design

74 participants in 3 patient groups

chlorthalidone

Treatment:

Drug: chlorthalidone

motivational invervention

Description:

motivational interview(s) vs. repeated calls vs. no particular intervention

Treatment:

Behavioral: motivational intervention for non-compliant individuals

standardized anti-hypertensive treatment

Treatment:

Drug: standardized anti-hypertensive treatment