Resistant Bacterial Infections in the Early Post LDLT Period

Ain Shams University

Status

Completed

Conditions

Transplantation Infection

Treatments

Procedure: Living donor liver transplantation

Study type

Observational

Funder types

Other

Identifiers

NCT02777632

2652010

Details and patient eligibility

About

The purpose of this work was to study the incidence, types, risk factors and causative organisms of bacterial infections in HCV Egyptian patients following Liver Transplantation. Moreover, to identify the emerging resistant strains and their proper antimicrobial therapy

Full description

This prospective descriptive study has been done at Tropical Medicine department in the period between January 2014 to November 2015.

After the approval of the scientific and ethical committee of Ain Shams University Hospital, Patients with HCV positive end stage liver disease (ESLD) eligible for liver transplantation Ain Shams Center for Organ Transplant (ASCOT); Ain Shams University, (fulfilling the inclusion criteria) were included in the current study. Forty five patients were recruited and each one was followed-up during a period of 3 months following transplantation.

Included patients were divided into 2 groups:

Group 1 included patients who had a postoperative single episode of infection. Group 2 included those patients who had more than 1 episode of postoperative bacterial infection whom were further evaluated for the presence of emerging strains and/or antibiotic resistance.

Enrollment

45 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Egyptian nationality.
Accepting participation in the current study and signing a written consent form
Age between 18-60 Years, including males and females.

Exclusion criteria

Patients who refused to be enrolled in the study.
Patients with other etiologies for end-stage liver disease (HBV, PBC...)
Patients with preoperative infections, infections within 48 h after transplantation or early post-operative death