Resolution of Allergic Inflammation

University Hospital, Strasbourg, France

Status: Completed

Conditions: Grass Pollen Allergic Rhinitis

Treatments: Other: Grass pollen allergen extract; Other: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01992835

5507

Details and patient eligibility

About

After an allergen challenge, the allergic inflammatory response disappears spontaneously. The initiation of the resolution of the inflammatory response is now recognized as a dynamic process, involving active biochemical programs that enable inflamed tissues to return to homeostasis. Recent data established key roles of different specific lipid mediators in the endogenous counter-regulation of inflammation and activation of resolution. Only little is known about kinetics of these specialized pro-resolving lipid mediators during acute allergic inflammation. Therefore, the primary propose of our study is to characterize the temporal evolution of cellular inflammation and specific lipid mediators after allergen challenge.

Enrollment: 20 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Eligibility criteria:

Inclusion Criteria

• Allergic rhinitis during the grass pollen season with or without asthma, with at least one of the following symptoms: nasal congestion, itching, rhinorrhea, sneezing
• Grass pollen sensitization determined by a positive skin prick test and / or presence of specific IgEs to a grass pollen allergen extract

Exclusion Criteria:

• Smoker
• Specific immunotherapy with grass allergens or other respiratory allergen for inclusion.
• Current exhibition to another clinically relevant respiratory allergen

Trial design

20 participants in 2 patient groups, including a placebo group

measurement of mediators in biological fluids

Placebo Comparator group

Treatment:

Other: placebo

Grass pollen allergen extract

Experimental group

Treatment:

Other: Grass pollen allergen extract