Resolvin D1 in Psoriasis Before and After Narrowband UVB Phototherapy

Cairo University (CU)

Status: Unknown

Conditions: Psoriasis

Treatments: Other: skin biopsy before and after NB-UVB phototherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03483311

Dermatology7

Details and patient eligibility

About

• Assessment of tissue level of resolvin D1 in psoriasis in comparison to its level in healthy controls in order to verify its role in the pathogenesis of psoriasis.

Enrollment: 30 estimated patients

Sex: All

Ages: 12+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with psoriasis (adults and children above 12years)
• Both sexes.
• New cases or cases not receiving any treatment for at least 3 months ago.

Exclusion criteria

• Any contraindication to phototherapy treatment (e.g. Photosensitizing creams or medications, past skin cancer, especially melanoma, etc...)
• Erythrodermic and pustular psoriasis.
• History of autoimmune diseases or other systemic diseases (e.g. Alzheimer's disease, fibromyalgia, cystic fibrosis)

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

psoriasis patients

Experimental group

Description:

Tissue levels of resolvin D1 in psoriatic patients before and after NB-UVB.

Treatment:

Other: skin biopsy before and after NB-UVB phototherapy

controls

Experimental group

Description:

Tissue levels of resolvin D1 in controls

Treatment:

Other: skin biopsy before and after NB-UVB phototherapy