Resolvin D1 Levels in Patients With Periodontitis

T.C. ORDU ÜNİVERSİTESİ

Status: Completed

Conditions: Periodontitis

Treatments: Procedure: periodontal therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04496570

Ordu University Dental Faculty

Details and patient eligibility

About

The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.

A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

Enrollment: 26 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Stage 3, Grade B and generalized periodontitis patients

Exclusion criteria

• excessive forces;
• presence of systemic diseases
• administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
• having received non-surgical periodontal treatment within the past 6 months
• allergy or sensitivity to any drug,
• pregnancy, lactation
• current and former use of tobacco.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

Periodontitis patients

Active Comparator group

Description:

gingival crevicular fluid and saliva collection were taken before and after nonsurgical periodontal treatment

Treatment:

Procedure: periodontal therapy

Healthy individuals

No Intervention group

Description:

gingival crevicular fluid and saliva collection were taken at baseline after oral hygiene instructions