Respiratory Disorder During Sleep in the Pregnancy : A Risk Factor in Gestational Diabetese

Public Assistance-Hospitals of Marseille (AP-HM)

Status

Unknown

Conditions

Respiratory Disorder in Patient With Gestational Diabetes

Treatments

Other: Respiratory disorder assessment during sleep

Study type

Interventional

Funder types

Other

Identifiers

NCT02756442

2015-41 (Other Identifier)

2015-A01796-43

Details and patient eligibility

About

Introduction:

The pregnancy brings about physiological and hormonal modifications which cause sleep disorder. The sleeplessness, snoring and a bad sleepquality are frequent during the pregnancy. Also a limited breathing airflow happens very often during the pregnancy. The limited airflow causes micro-awakenings that enter in the frame of the high resistances airways syndrome. To our knowledge there is no study about the outcome of micro-awakenings at pregnant women.

Objectives:

To compare the prevalence of the high resistances airways syndrome (RERA) in pregnant woman with or without gestational diabetes

Methods :

It is a monocentrical prospective study at pregnant women after the 30th amenorrhea week who consul the gynecologie and obstetrics department of the CHU NORD in Marseille. We are going to compare the breathing disorder during sleep of a control group with a group of women with gestational diabetes. A polysomnograph will be run at the included patients' home.

Expected results :

The physiological and hormonal modifications during the pregnancy could favor nocturnal sleep events (snoring, SAHOS and RERA) and its complications as gravidic HPN And gestational diabetes cause maternal and fœtal and morbidity and mortality. We put the hypothesis that limited airflow in association with micro-awakenings in the RERA have a negative impact on the glucose metabolism and favor the gestational diabetes.

Enrollment

40 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Pregnant woman in the 3rd quarter of pregnancy (24 to 32 weeks amennorhea).

Presenting a gestational diabetes ou not (=controle group)
Written and signed consent.

Exclusion criteria

Twin pregnancy
High blood pressure before pregnancy
Diabetes diagnosed before pregnancy
Left ventricular ejection fraction below 40%
Alcohol consumption (more than 7 glaces/day), drugs of type hypnotic, sedative, opioids
History of gestational diabetes or glucose intolerance
Severe cronical respiratory impairment (severe asthma)
Creatinine clairance below 60 mL/min