Respiratory Effects of Dopamine in the Perioperative Care (DOPHUMAN)

University of Szeged (SZTE)

Status: Unknown

Conditions: Functional Disturbance; Heart; Bronchodilation; Surgery; Dopamine

Treatments: Drug: Dopamine administration

Study type: Interventional

Funder types: Other

Identifiers

NCT04753008

DOPHUMAN

Details and patient eligibility

About

Dopamine is frequently used as an inotropic drug to elevate cardiac output. In addition to the beneficial cardiac effect of this drug, the few previous studies addressing its ability to alter the airway tone reported controversial results.

Thus, the investigators aimed at clarifying the potential of dopamine to alter gas exchange outcomes and the airway tone in patients undergoing cardiac surgeries with cardiopulmonary bypass.

Blood gas parameters, airway resistance, tissue damping and tissue elastance will be measured in the patients before the CPB, immediately after CPB, and 5 min after administration of dopamine (3 mcg/kg/min).

The importance of the research is to reveal whether the beneficial mechanical changes after dopamine administrations are associated with improvements in gas exchange outcomes. Clarification of this research question have scientific relevance and may also improves patient outcomes.

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cardial surgery patients undergoing cardiopulmonary bypass procedures

Exclusion criteria

• Chronic respiratory diseases, elderly (>80 years)

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Dopamine group

Experimental group

Description:

Cardiac surgery patients receiving dopamine to support their cardiac function (as part of the routine post-operative care).

Treatment:

Drug: Dopamine administration

Control group

No Intervention group

Description:

Cardiac surgery patients receiving no positive inotrope drug.