Respiratory Effects of E-Cigarettes in Obese Youth (RESEC)

The Ohio State University

Status

Active, not recruiting

Conditions

E-Cig Use

Treatments

Other: ECIG own

Other: ECIG Vuse

Study type

Interventional

Funder types

Other

Identifiers

NCT05869318

OSU-22219

NCI-2023-04458 (Registry Identifier)

Details and patient eligibility

About

To determine vaping behaviors and respiratory function in obese and nonobese youth e-cigarette users.

Full description

The investigators hypothesize that obese youth e-cigarette users will have increased e-cigarette use that will worsen respiratory function. The approach will involve a clinical trial where vaping behaviors (using puff topography) and respiratory function (spirometry, plethysmography, and diffusion capacity) will be assessed while participants vape with their own e-cigarette and, on a separate visit, with the VUSE e-cigarette.

Enrollment

56 patients

Sex

All

Ages

21 to 25 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

a current e-cigarette user (≥1 vaping bout daily) for at least the past 3 months,
21-25 years old,
willing to abstain from all tobacco and nicotine for at least 12 hours prior to lab sessions,
willing to complete five lab visits lasting up to 4 hours each,
able to read and speak English,
willing to provide informed consent.

Exclusion criteria

self-reported diagnosis of lung disease including asthma or cystic fibrosis
history of cardiac event or distress within the past 3 months
history of metabolic disease including thyroid disease or diabetes
history of orthopedic or neuromuscular problems that preclude exercise
currently pregnant (determined using urine pregnancy test), planning to become pregnant, delivered a child in the past 6 weeks even if not breastfeeding, or currently breastfeeding
use of other tobacco products >10 days in the past month
current marijuana use >10 times per month
currently engaging in a vaping cessation attempt
) competitive athlete or individual currently engaged in an exercise training program involving 420min or more (moderate intensity aerobic activity) or 210 min or more (vigorous intensity aerobic activity) per week with the goal of participating in a competitive event or marathon, triathlon, etc. Participants who are engaged in usual physical activity (e.g., walking dog, biking to work, etc.) but not engaged in a "structured exercise training program" will not be excluded.
plans to leave the Columbus or central Ohio region within the next year.