Respiratory Effects of Perioperative Oxygen During General Anaesthesia
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About
Aim: To investigate the effect of high intra- and postoperative oxygen concentration (80%, as opposed to normally 30%) on pulmonary gas exchange and other pulmonary complications after abdominal surgery.
Background: Previous studies have shown possible beneficial effects of high perioperative oxygen concentration on surgical wound infection and healing, but all pulmonary effects are not clarified. Change in perioperative PaO2/FiO2 and shunt-fraction, measured by a gas rebreathing technique, can describe pulmonary oxygenation. This could add knowledge to the pulmonary effects of high vs. normal oxygen concentration.
Primary hypothesis of study: Perioperative use of a 80% oxygen concentration reduces the PaO2/FiO2-index compared to 30% oxygen.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Age 18 years or older
- Laparatomy, elective
Exclusion criteria
- Inability to give informed consent
- Chemotherapy within 3 months
- Other surgery within 30 days(except surgery in local anaesthesia)
- Inability to keep oxygen saturation above 90% without supplemental oxygen (measured preoperatively by pulse oximetry)
Trial design
Primary purpose
Allocation
Interventional model
Masking
35 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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