Respiratory Functions in Pediatric-Onset Multiple Sclerosis

Istanbul University - Cerrahpasa (IUC)

Status: Unknown

Conditions: Pediatric-onset Multiple Sclerosis

Treatments: Other: Evaluation of respiratory capacity, respiratory muscle strength and fatigue

Study type: Observational

Funder types: Other

Identifiers

NCT05123924

IUC-2021-68

Details and patient eligibility

About

Pediatric-onset multiple sclerosis (POMS) is a chronic, autoimmune and inflammatory disease of the central nervous system that begins before the age of 18 years. POMS patients are affected in terms of physical capacity, cognitive status and fatigue compared with their healthy peers that has been reported. It has been reported that although individuals with MS with low disability levels do not have respiratory complaints, respiratory parameters may be affected. Therefore, it is necessary to evaluate respiratory capacity, respiratory muscle strength and fatigue levels of POMS patients. Evaluations will help prevent future complications by detecting any existing problems early.

Full description

People with pediatric onset multiple sclerosis (POMS) may experience sensory, motor, cerebellar and cognitive dysfunctions due to the destruction of the central nervous system. These disorders can cause decrease in physical capacity, increase in cognitive symptoms and fatigue level in patients with POMS. There is no study in the literature examining the relationship between respiratory capacity and respiratory muscle strength with fatigue in POMS patients. The aim of this study is to compare POMS patients and healthy controls in terms of respiratory capacity, respiratory muscle strength and fatigue. All participants's respiratory function will be evaluated with "Minispir Light Spirometer", respiratory muscle strength with "MD Diagnostics RP Check" and fatigue with Pediatric Quality of Life Inventory (PedsQL)-Multidimensional Fatigue Scale. Evaluations will not be repeated after a certain interval.As a result of the comparison of both groups, it will be determined whether POMS patients have difficulties or not.

Enrollment: 46 estimated patients

Sex: All

Ages: 15 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Volunteer to participate
• Being diagnosed with pediatric onset multiple sclerosis
• Being between the ages of 15-22
• EDSS <6

Exclusion criteria

• Having another diagnosis in addition to the diagnosis of pediatric-onset multiple sclerosis
• Having a blurred vision problem
• Having had an attack or received corticosteroid treatment 3 months before participating in the study

Trial design

46 participants in 2 patient groups

POMS Group

Description:

Individuals in the POMS group will be evaluated in terms of respiratory capacity, respiratory muscle strength and fatigue.

Treatment:

Other: Evaluation of respiratory capacity, respiratory muscle strength and fatigue

Control Group

Description:

Individuals in the control group will be evaluated in terms of respiratory capacity, respiratory muscle strength and fatigue.

Treatment:

Other: Evaluation of respiratory capacity, respiratory muscle strength and fatigue